A process where irregular tissue is frozen and destroyed using a device known as a cryoprobe or an extremely cold liquid. The same applies to cryotherapy and heat therapy for injury recovery. Numerous medical conditions are treated using cryotherapy, including pain management, lowering fever, controlling bleeding, preventing or treating edema from trauma and inflammation, reducing spasticity, and reducing pain. The first 24 to 48 hours after an injury are when cold is typically applied. Reduced fluid filtration into the tissue interstitium, reduced discomfort and inflammation, and a slower metabolic rate are often the outcomes of applying cold first.